TITLE:
The Synergy of Combined Use of DMSO and Bronsted Acid (Ionic Liquid) as a Catalyst Part I: Efficient Niementowski Synthesis of Modified Quinazolinones
AUTHORS:
Muthu K. Kathiravan, Rajeshwar R. Jalnapurkar, Trupti S. Chitre, Riyaj S. Tamboli, Kumar V. Srinivasan
KEYWORDS:
Ionic Liquids, DMSO, Niementowski
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.1,
February
25,
2011
ABSTRACT: A new rapid and versatile approach using Ionic liquid/DMSO as a chemical reagent for the synthesis of fused heterocyclic compounds in a highly efficient way is described. This method offers the advantages of proceeding in neutral conditions, giving high to excellent isolated yields (83–92%) for Niementowski synthesis with easy workup procedure. The inherent Bronsted acidity of ionic liquid and high polarity of both IL and DMSO resulted in a significant enhancement in the reaction rate.