TITLE:
Variable β-globin haplotypes in Saudi β thalassemia population
AUTHORS:
Jameela Shinwari, Tahani Alshehri, Asma I. Tahir, Abdullah Al Jefri, Abdulkareem AlMomen, Dana Bakheet, Mohammad AlAnazi, Arjumand Warsy, Nada Al Tassan
KEYWORDS:
SNPs; Haplotype; Linkage Disequilibrium; Restriction Sites
JOURNAL NAME:
Open Journal of Genetics,
Vol.3 No.3,
August
28,
2013
ABSTRACT:
Twenty two haplotypes were generated from a pool of
60 unrelated Saudi β thalassemia
major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis
of the polymorphic sites was also conducted, a few identified haplotypes were
novel while the remainder was previously reported, haplotype1222212 was the
most frequent haplotype in the study group and a strong linkage disequilibrium
between two polymorphic restriction sites in these β thalassemia patients was uncovered.