TITLE:
Are Lipid Panels Altered by a Large Lunch Meal in Type 2 Diabetes?
AUTHORS:
Elizabeth Duran-Valdez, Absalon D. Gutierrez, David S. Schade
KEYWORDS:
Lipid Profile; Type 2 Diabetes; Fed vs. Fasting State
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.2,
May
23,
2013
ABSTRACT:
Introduction: Recently, analyses of large heterogeneous databases have suggested
that there are no differences whether “lipid panels” are drawn in the fed or
fasted state, even in diabetic individuals. Whether this is true for individual
diabetic patients is unknown. Methods: We studied eight type 2 diabetic individuals and measured serial lipid panels
to determine the effect of a large lunch meal. A “Big Mac” equivalent meal was
fed to each volunteer and blood for lipid assays was obtained at baseline and
hourly for five hours following the meal. Results: The meal induced a significant elevation of glucose, insulin, and c-peptide
in each volunteer. In addition, the following lipid parameters significantly
changed from baseline concentration during the meal: total cholesterol, non-HDL
cholesterol, LDL-cholesterol and triglycerides. Furthermore, the timing of the
blood draw post meal also was a determinant of the lipid concentration. No
significant concentration change occurred in HDL-cholesterol. Conclusions: In type 2 diabetic
patients, lipid panels should be drawn in the fasting state unless the only
lipid parameter of interest is HDL-cholesterol.