Hanna, R.M., Tran, N., Patel, S.S., Hou, J., Jhaveri, K.D., Parikh, R., et al. (2020) Thrombotic Microangiopathy and Acute Kidney Injury Induced after Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors VEGF Blockade-Related TMA after Intravitreal Use. Frontiers in Medicine, 7, Article 579603.
https://doi.org/10.3389/fmed.2020.579603

has been cited by the following article:

• TITLE: Intravitreal Injection of Bevacizumab Induced TMA: A Case Report

  AUTHORS: Nada Zagdouni, Mohamed Amine Khalfaoui, Benyounès Ramdani

  KEYWORDS: Vascular Endothelial Growth Factor (VEGF), Thrombotic Microangiopathy (TMA), Bevacizumab, Renal Toxicity, Intravitreal Injection

  JOURNAL NAME: Open Journal of Nephrology, Vol.15 No.3, July 25, 2025

  ABSTRACT: The use of vascular endothelial growth factor (VEGF) inhibitors, particularly anti-VEGF agents like Bevacizumab, has become a cornerstone in the treatment of proliferative diabetic retinopathy and diabetic macular edema. While systemic renal side effects of these agents are well-documented, emerging evidence suggests that intravitreal administration may also be associated with significant renal risks. We report the case of a 32-year-old male with a 25-year history of type 1 diabetes who developed thrombotic microangiopathy (TMA) following intravitreal Bevacizumab injections. Diagnostic evaluations ruled out other causes, leading to a diagnosis of drug-induced TMA. Treatment included corticosteroids and plasma exchange, but renal function did not recover, necessitating hemodialysis. This case underscores the critical need for renal monitoring in patients receiving anti-VEGF therapy, particularly those with preexisting renal impairment, to mitigate the risk of serious renal complications.