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has been cited by the following article:

• TITLE: Cytotoxic and Cell Proliferation Activities of Isocoumarin Derivatives Isolated from Phialocephala scopiformis FC-1873

  AUTHORS: Yuji Higashira, Daigo Wakana, Yuji Doi, Hisashi Takeda, Nobutomo Ikarashi, Satoshi Kitaoka, Fumiaki Sato, Hiyori Itagaki, Tsuyoshi Hosoya, Tomoo Hosoe

  KEYWORDS: (+)-Phaeosphaerin A, (S)-6-Demethylkigelin, Cytotoxicity, Cell Proliferation Effect, Phialocephala scopiformis

  JOURNAL NAME: Advances in Microbiology, Vol.15 No.5, May 30, 2025

  ABSTRACT: Phialocephala scopiformis (Ascomycota, Helotiales, Mollisiaceae) are fungi known as both saprophytes and endophytes, forming small apothecia (1 - 3 mm in diameter) on decaying wood. In this study, three novel isocoumarin derivatives (+)-phaeosphaerin A (1), (+)-phaeosphaerin B (2), and (S)-6-demethylkigelin (3) were isolated from Phialocephala scopiformis FC-1873 collected in Japan, along with two known isocoumarins, lignicol (4) and 6,8-dihydroxy-3,5-dimethyl-1H-2-benzopyran-1-one (5). The cytotoxicity of 1 and 4 were evaluated against HL-60, PANK-1, HepG2, HT-29, and T98G cell lines, as well as their effects on cell proliferation in the skin keratinocyte cell line HaCaT. These findings highlight the potential of mollisioid fungi as a source of novel bioactive compounds.