TITLE:
Recent Advances in Photoenzymatic Catalysis
AUTHORS:
Caiyi Xiang
KEYWORDS:
Photoenzymatic, Biocatalysis, Biocatalysts, ERED, “Ene”-Reductases, Nitroreductases, Flavin
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.14 No.2,
June
20,
2024
ABSTRACT: Photoenzymatic catalysis has become an emerging field in organic synthetic chemistry that provides eco-friendly alternatives to traditional methods. This comprehensive review examines the developing field of photoenzymatic catalysis, categorized by reaction types and focusing on its application in organic synthesis. This article highlights recent advances in the use of photoenzymatic reactions in carbon-carbon cross-coupling, ketone and alkene reduction, hydroamination, and hydrosulfonylation, mostly by flavin-dependent “ene”-reductases and nitroreductases. In each case, we exemplified the substrate scope that produces products with high yield and enantioselectivity. Additionally, the emerging trends in developing new enzymatic variants and novel reaction pathways that broaden the scope and enhance yield of these reactions were discussed.