TITLE:
Male and Female Hypogonadisms: Etiological, Metabolic and Osteodensitometric Aspects
AUTHORS:
Nestor Ghislain Andzouana Mbamognoua, Ikram Damoune, Sana Doubi, Asmae Lahlou, Farida Ajdi
KEYWORDS:
Hypogonadism, Etiological, Metabolic, Osteodensitometric, Fez
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.14 No.2,
February
20,
2024
ABSTRACT: Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia,
type 2 diabetes in cases of low testosterone in men and which are associated with
increased cardiovascular risk. Hypogonadism
represents the second cause of endocrine osteoporosis. Objectives: The objectives
of our work were: to determine the main causes of hypogonadism in women and men;
to assess the frequency of metabolic and osteosdensitometric abnormalities in the
hypogonadal population. Patients and methods: A retrospective descriptive
study was carried out over 7 years on 120 patients, hospitalized in the Endocrinology
department of the Hassan II University Hospital of Fez-Morocco for hypogonadism.
The patients selected were those who had symptoms of hypogonadism confirmed in men
by: low total testosterone for Tanner stage in adolescents, ng/ml or
lower limit of normal for adults; in women, hypoestrogenia 30 pg/l. Gonadotropin
dosage, karyotype, pelvic or testicular ultrasound and pituitary MRI, for etiological
diagnosis, were performed. Bone densitometry was performed for bone impact and lipid
profile for metabolic profile. Results: Out of 120 patients, there were 77 women and 43 men.
The average age was 31.51 years. In men, the main causes were central hypogonadism
in 67.4% and primary testicular failure in 32.6%. In women, central hypogonadism
was also the most common cause noted in 63.7% and premature ovarian failure was
observed in 36.4%. HypoHDL was significantly more frequent p (0.005) in women, osteopenia and
osteoporosis were significantly more frequent in women than in men p (0.046). Conclusion: Central causes represent the most common etiology of
hypogonadism in both sexes; abnormalities of bone mineralization and metabolic disorders
were predominant in women.