TITLE:
Macrophage Activation Syndrome in a Context of Pre-B Type Lymphoblastic Acute Leucemia: A Case Report
AUTHORS:
Mamadou Wagué Gueye, Sokhna Moumi Mbacké Daffé, Mor Ngom, Maguette Ndoye, Papa Silman Diawara, Nata Dieng, Demba Makalou, Macoura Gadji, Macoura Gadji, Awa Oumar Touré/Fall, Bécaye Fall
KEYWORDS:
Macrophage Activation Syndrome, Acute Lymphoblastic Leukemia, Adult
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.13 No.4,
December
8,
2023
ABSTRACT: Macrophage
activation syndrome (MAS) is linked to inappropriate stimulation of macrophage
cells in the bone marrow and lymphoid system, resulting in abnormal phagocytosis of figurative blood elements and the release of pro-inflammatory cytokines. It is a rare and
serious hyper-inflammatory condition of diagnostic and therapeutic
emergency. MAS is characterized by non-specific clinical and laboratory signs
associated with images of hemophagocytosis. MAS is either “primary” (familial
or pediatric forms), or “secondary/reactive”
to infection, neoplasia, or autoimmune disease. Hemopathies dominate MAS
secondary to neoplasia. B-type acute lymphoblastic leukemia (ALL) is a
hematological malignancy characterized by the proliferation and accumulation of
B lymphoid progenitors, blocked at an early stage of differentiation, leading to suppression of polyclonal
hematopoiesis and subsequent development of signs associated with bone marrow
failure. In this context, we report the observation of a macrophage
activation syndrome (MAS) associated with ALL, diagnosed at Hôpital Principal
de Dakar/Senegal, in a 69-year-old patient with a well-controlled type 2
diabetes under oral antidiabetic therapy (OAD) and good general condition.