TITLE:
Gynecological Side Effects of Tamoxifen among Sudanese Women, Khartoum, Sudan, 2020
AUTHORS:
Mawahib Ahmed Elawad Abu Elgasim, Yousra Abdelmoniem Suleiman, Lobaina Abozaid, Dlal Alser Hassan Mohmmed, Soha Saad Aldin Mohamad Suliman, Duaa Hamd Abdulatif Farh
KEYWORDS:
Tamoxifen, Breast Cancer, Gynecological Side Effects, Sudanese Women
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.12 No.4,
October
19,
2023
ABSTRACT: Background: In Sudan, the common endocrine therapy tamoxifen is prescribed to HR-positive
patients, which is associated with a variety of complications such as hot
flashes, vaginal discharge, and vaginal dryness. Objective: This study
aimed to determine the gynecological side effects of tamoxifen among Sudanese
women who have been diagnosed with breast cancer in Khartoum, Sudan. Methods:
A retrospective cross-sectional study was conducted at Alzara Hospital in Al
Amal Toure Revere, Sudan. A convenience sample of individuals previously
diagnosed with breast cancer attended refer clinic. From October 2020 to
September 2021, all patients attending were checked for eligibility. Results:
A total of 100 patients were enrolled in the study; 60% of patients reported
increased vaginal secretions after taking the drug, 28% reported normal vaginal
secretions with no change, and 11% reported decreased secretions after taking
the medication, while 22% developed vaginal bleeding, and 22% of the ultrasound
results revealed endometrial masses among the study patients. Also, 54 percent
of female patients experienced hot flashes after taking the medication, and 12%
of women missed some doses of treatment. Conclusion: Tamoxifen results
in several gynecological side effects in women with breast cancer. A high
percentage of women in the study developed hot flashes, vaginal bleeding, and
discharge, in addition to having ultrasound results showing endometrial masses
among them.