TITLE:
The CircRNAs for Diagnostic, Prognostic, and Therapy in Alzheimer’s Disease
AUTHORS:
Erika Alejandra Cabrera-Reyes, Miguel Alejandro Jiménez-Acosta, Mayte Lizeth Padilla-Cristerna, Marco Antonio Meraz-Ríos
KEYWORDS:
CircRNA, Alzheimer’s Disease, miRNAs, Diagnosis, Therapy, Dementia
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.13 No.12,
December
21,
2022
ABSTRACT: The structure and biological function of circular
RNAs (circRNAs) in regulating gene expression in a cell is far from known.
CircRNAs are unique molecules that contain potent regulatory elements. CircRNAs
actively interact with miRNAs (sponging), affecting their regulation and
functions. In addition, circRNAs have roles in transcriptional regulation,
splicing, and peptide synthesis. With all these properties, circRNAs could play
an essential role in diseases, especially Alzheimer’s. Their role in early
diagnosis, previous to present symptoms, prognosis associated with
neuropathological AD of specific circRNAs, and one of their primary functions
is to act as a sponge for miRNAs, which could be a starting point for future
gene therapy. This review aims to summarize the current knowledge of these exciting
molecules and their potential use as new markers for AD risk. This article will
focus on circRNAs deregulated in Alzheimer’s.