TITLE:
Breast Carcinoma Arising in Fibroadenoma in a 15-Year-Old Girl; Diagnosis and Treatment Challenge
AUTHORS:
Malala Razakanaivo, Toky Rakotoarivo, Ny Ony Andrianandrasana, Florine Rafaramino
KEYWORDS:
Adolescent, Breast Carcinoma, Fibroadenoma, Mastectomy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.10,
October
17,
2022
ABSTRACT: Breast
cancer in adolescents occurring in fibroadenomas is extremely rare. We report a case of right breast cancer in a
15-year-old female student diagnosed in 2020. This is the youngest reported
case of breast cancer arising within fibroadenomas in the literature.
The teenager has no personal or family history of cancer or known hereditary
disease. Currently, there is no consensus on the management of breast cancer
arising from adenofibromas in adolescents. Clinically, the tumor was inflammatory
with axillary lymph node involvement (T4dN1M0). The fine-needle aspiration
cytologic was suspicious of malignancy. The patient received four courses of
neoadjuvant chemotherapy with 5-fluorouracil®, doxorubicin® and
cyclosphosphamide®, followed by radical right mastectomy. The histological
result of the surgical specimen is a non-specific carcinoma with a therapeutic
effect greater than fifty percent. The patient received three courses of
adjuvant chemotherapy with paclitaxel®. The
adolescent underwent radiation therapy at her chest wall of 50 Gy and
regional lymph node of 46 Gy. After radiotherapy, hormone therapy with Tamoxifene® at 20 mg per day
was started. At 16 months from radiotherapy, there is no recurrence. The
reconstruction of the right breast is planned in a few months.