TITLE:
Clinical, Biological, Immunological and Therapeutic Profile of Patients Co-Infected with HIV-HBV and/or HCV in Kinshasa, in the Democratic Republic of the Congo: Multicenter Cross-Sectional Study
AUTHORS:
Jean-Paul Mayimona Kimpiatu, Aliocha Natuhoyila Nkodila, Antoine Wola Yaba Tshimpi, Charles Nlombi Mbendi, Thérèse Ndarabu, Jean Jacques Matimbo, Youyou Paka, Patrick de Jésus Ngoma, Blaise Batumona, Trésor Monsere, Pitchou Kengibe, Jean Robert Rissassi Makulo, Mireille Nganga, Hippolyte Nani-Tuma Situakibanza, Benjamin Longo Mbenza
KEYWORDS:
HIV-HCV-HBV Co-Infection, Clinical Profile, Biology, TARVs, Kinshasa
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.12 No.4,
April
15,
2022
ABSTRACT: Background and
Objective: HIV infection is often associated with HBV and HCV
infection, together leading to high morbidity and mortality in developing
countries. The objective of this study is to describe the clinical, biological,
immunological and therapeutic profile of patients co-infected with HIV-HBV
and/or HCV. Methods: A cross-sectional and descriptive study including
180 people living with HIV (PLWHIV) in the city of Kinshasa province was
conducted. Socio-demographic,
clinical, biological and serological characteristics were analyzed. Results: The frequency of HIV-HBV/HCV co-infection was 23.9%. The distribution of age
and sex of patients did not differ significantly according to co-infection
status. The notion of pedicure and manicure was significantly more observed in patients
free from viral hepatitis (51.1% versus 32.6%, p = 0.034). The median duration of knowledge of the HIV status which was
longer in the co-infected (4 years versus 2 years, p = 0.022). A lower median level of GPT was observed in co-infected
compared to other patients (14 IU/L versus
20 IU/L, p =
0.041). Serum albumin (3.1 g/L versus 3.3 g/L, p = 0.034) and prothrombin
(58.3% versus 65.6%, p = 0.045) were lower in
HIV co-infected-VHB and/or VHC. The median INR was higher in co-infected than
in other patients (1.6 versus 1.4; p = 0.009). Patients
without therapy Antiretroviral (TARV)
medication were more numerous in co-infected (20.9% versus 8.0%, p =
0.025). Conclusions: The profile of PLWHIV was dominated by the presence of pedicures and manicures with high transaminases and
without anti-viral treatment.