TITLE:
In the Basis of Hashimoto’s Thyroiditis, to Form Papillary Thyroid Carcinoma, Metastasized and Then to De-Differentiate into Poorly Differentiated Squamous Cell Carcinoma
AUTHORS:
Xinle Ren, Di Zhu, Hen Wang, Jilin Wang, Biyun Lin, Yongfang Ou, Bing Huang, Jian Huang
KEYWORDS:
Papillary Thyroid Cancer, Thyroid Squamous Cell Carcinoma, Pathomorphology, Molecular Pathology, Multidisciplinary
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.5,
May
19,
2021
ABSTRACT: Thyroid squamous cell carcinoma is very rare. At present, it is limited
to case reports. Since the thyroid follicular epithelium is the non-squamous
epithelium, how primary squamous cell carcinoma (SCC) of the thyroid occurs is
still a controversial issue. Hashimoto’s thyroiditis (HT) is considered to be
an independent risk factor for thyroid cancer, under the basis of HT, how tumor
cells evolve and develop to papillary thyroid carcinoma (PTC), and particularly
to de-differentiate into SCC is elusive. We report a 72-year-old female patient
who developed multiple subtypes of PTC on a basis of HT, and finally to
de-differentiate into SCC within the local foci of lymph node metastasis. We
found that there was a variety of sub-types of PTC in this patient in the
background of HT. SCC was found within local lymph node metastasis.
Pathomorphology, immunohistochemistry, and molecular pathology have confirmed
that the SCC was derived from PTC, and then developed into poorly
differentiated SCC and/or anaplastic carcinoma. We also conducted a
comprehensive literature review.