TITLE:
Syntheses, Characterization and Biological Activity of Coordination Compounds of 3-Hydroxy-2-methyl-4H-pyran-4-one and Its Mixed Ligand Complexes with 1,2-Diaminocyclohexane
AUTHORS:
Temitayo O. Aiyelabola
KEYWORDS:
Coordination Compounds, Cytotoxicity, Antioxidant, Mixed Ligand Complexes, 3-Hydroxy-2-methyl-4H-pyran-4-one 1, 2-Diaminocyclohexane
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.11 No.3,
May
14,
2021
ABSTRACT: Coordination compounds of 3-hydroxy-2-methyl-4H-pyran-4-one with iron(III), cobat(III) and chromium(III) were
synthesized with M:L (1:2). Mixed ligand coordination compounds of
3-hydroxy-2-methyl-4H-pyran-4-one and 1,2-diaminocyclohexane using the
same metal ions were also synthesized M:L1:L2 (1:1:1) where L1 is 3-hydroxy-2-methyl-4H-pyran-4-one and L2 is
1,2-diaminocyclohexane. The coordination compounds obtained were characterized
using electronic and infrared spectral analyses, magnetic susceptibility and
percentage metal analysis. They were also evaluated for their cytotoxic and antioxidant
activities. The result obtained suggested that octahedral geometry was obtained
for all the compounds, as a result of additional two molecules of the solvent
coordinated to the metal ions. Both the primary and secondary ligands
coordinated in a bidentate fashion. The synthesized compounds exhibited
moderate cytotoxicity, although none was as active as the standard. The
cobalt(III) mixed ligand complex elicited the highest activity. The synthesized
compounds all exhibited good to moderate antioxidant activity.