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has been cited by the following article:

• TITLE: Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene

  AUTHORS: Tuo Nanou Tiéba, Kangah Niameke Jean Baptiste, Ballo Daouda, Kablan Ahmont Landry Claude, Kodjo Charles Guillaume, Yapo Ossey Bernard, Ziao Nahossé

  KEYWORDS: Perimidine, Spectrometry, Antioxidant Activity, 2, 2-Diphenyl-1-Picrylhydrazyl Method and Ferric Reducing Antioxidant Power Method

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.12 No.1, February 9, 2021

  ABSTRACT: From (2,3-dihydro-1H-perimidin-2-yl)-phenyl, the substitution of OH group in ortho or para position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in para position has the lowest activity in both cases. Therefore the para position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.