TITLE:
An Antibacterial Wound Dressing Based on GS-SF Composite Scaffold
AUTHORS:
Qifeng Jiang, Ping Chen, Bin Gao
KEYWORDS:
Silk Fibroin, Gentamicin Sulfate, Wound Dressing, Anti-Bacterial
JOURNAL NAME:
Health,
Vol.12 No.8,
August
10,
2020
ABSTRACT: Although the treatment of burn wounds has made great progress, the incidence of wound infection is still the main cause of high mortality. In this study, a silk fibroin (SF) scaffold wound dressing incorporated with Gentamicin Sulfate (GS) was developed for the treatment of burn infected wounds, in which GS was used as anti-bacterial agent. GS was mixed with silk fibroin solution and then processed into GS-SF composite scaffold via electro-spinning. The results showed the scaffold exhibited uniform polyporous morphology with 80% porosity. Induced by methanol, the scaffold presented much improved mechanical properties and stability to protease XIV. More important, the scaffold presented significant growth inhibition on both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.