TITLE:
Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo
AUTHORS:
Daddy Kabamba Numbi, Dophie Tshibuela Beya, Guelord Mukiapini Luzolo, Passy Kimena Nyota, Placide Cyanga Ngandu, Mamy Ngole Zita, Gustave Ilunga Ntita, Donatien Kayembe Nzongola-Nkasu, Jérémie Muwonga Masidi, Mireille Nganga Nkanga, Justin Mboloko Esimo, Arsène Mputu Lobota, Jean Bosco Kasiam Onkin, Baudouin Buassa-bu-Tsumbu, Cathy Ali Risasi, Fons Verdonck, Bernard Spitz, Jean Pierre Elongi Moyene
KEYWORDS:
PCOS, HbA1c, Subfertility, Congolese Women
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.11,
November
14,
2019
ABSTRACT: Context: Polycystic ovary syndrome
(PCOS) is considered a syndrome related to the
metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the
glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of
hyperglycemia that may be associated with this syndrome and to understand her
pathophysiology. Aims: The purposes of this study are to determine the profile
of HbA1c in Congolese women with PCOS, to determine the frequency of states of
hyperglycemia and to assess the impact of this marker on clinical signs on this
syndrome. Material and methods: This is a case-control study of 130 Congolese
subfertile women; 65 with a diagnosis of PCOS and
65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of
childbearing age. All these women were recruited at the subfertility outpatient
clinic of the University Hospital of UNIKIN as well of the YANGA medical
centers in Kinshasa, Democratic Republic of Congo. Sickle
cell disease was excluded as also the cases of anemia. HbA1c was assayed via the
immunoturbidimetric method and the results interpreted according to the ADA
recommendations with a pathological cut-off
point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1
g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568).
The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1%
vs. 5.6% ± 0.6%, P 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and
PCOS (OR 14.79 (CI 5.43 - 40.32), P 0.001). In the
PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status
(OR 3.38 (1.67 - 8.47), P = 0.018) and with
obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect,
positive and significant linear correlation was found between HbA1c and fasting
blood glucose (r = 0.807). 60% of women in the PCOS group had pathological
values of HbA1c (≥6.5%)
co