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https://doi.org/10.1073/pnas.160105897

has been cited by the following article:

• TITLE: Cannabidiol (CBD) Prevents Palmitic Acid-Induced Drop in Mitochondrial Membrane Potential

  AUTHORS: R. Gallily, Z. Yekhtin, M. Tarshis, R. Vogt Sionov

  KEYWORDS: CBD, Mitochondrial Membrane Potential, Macrophages, Microglia, Palmitic Acid

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.10 No.9, September 11, 2019

  ABSTRACT: Exposure of macrophages and microglia cells to the saturated palmitic acid (PA) leads to reduction in the mitochondrial membrane potential (), shrinkage of the cells and apoptosis. Here we show that the Cannabis component Cannabidiol (CBD) rescues both macrophages and microglia cells from the detrimental effects of PA. CBD prevents the shrinkage in cell size and the reduction incaused by PA. The protective effect of CBD on the macrophage mitochondria is important for sustaining the macrophage population even under the immunosuppressed conditions caused by this drug. To a similar extent, the antagonistic effect of CBD on PA-mediated microglia cytotoxicity is important for its role in neuroprotection.