TITLE:
Anthocleistenolide B, a New Secoiridoid from Anthocleista liebrechtsiana De Wild & T. Durand
AUTHORS:
Francis T. Ngouafong, Roland T. Tchuenguem, Jonas Kühlborn, Billy T. Tchegnitegni, Beaudelaire K. Ponou, Rémy B. Teponno, Jean P. Dzoyem, Till Opatz, Léon A. Tapondjou
KEYWORDS:
Anthocleista liebrechtsiana, Anthocleistenolide B, Antimicrobial Properties
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.9 No.4,
July
19,
2019
ABSTRACT: Drug resistance due to the extensive abuse and over-use of antibiotics
has become an increasingly serious problem and researchers started to use
plants as an alternative source of new antibiotics. The aim of the present
study was to assess the antimicrobial properties of secondary metabolites
isolated from A. liebrechtsiana. A
new secoiridoid derivative, anthocleistenolide B (1), along with three
known compounds, the monoterpene diol, djalonenol (2), the xanthone O-glycoside, decussatin 1-O-β-D-glucopyranoside
and the fatty acid, dotriacontanoic acid (4) was isolated from the leaves and bark of this plant. Their structures were
elucidated by extensive analysis of spectroscopic (1D and 2D NMR) and mass
spectrometric data. The isolated compounds were screened for their
antimicrobial properties against five strains of bacteria (two gram positive: Staphylococcus aureus 29213, Enterococcus faecalis ATCC 25922 and
three gram negative: Escherichia coli ATCC51299, Proteus mirabilis (isolate), and Pseudomonas aeruginosa QC76110), but all
were inactive.