TITLE:
Amorphous Calcium Salt Composition Bioavailability Evaluation in Chickens
AUTHORS:
D. Babarykin, M. Mutalova, G. Smirnova, S. Vasiljeva, G. Krumina, N. Basova, V. Agejchenko, R. Simanis
KEYWORDS:
Calcium Absorption, Amorphous Calcium, Experimental Rickets, Chicken
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.7 No.2,
January
23,
2019
ABSTRACT: Despite
the market saturation with a wide range of calcium preparations in dietary supplements as
well as in pharmaceuticals, calcium product safety and efficacy remain an item
for further optimization. Bones and teeth mainly consist of calcium phosphate,
but tablets and capsules are predominantly produced from calcium carbonate. On
the other hand, in human food Ca2+ is bound with a lot of anions—carbonates,
sulphates, chlorides, phosphates, citrates, oxalates etc. It seems that
traditional calcium formulations due its low bioavailability cannot provide all
spectra of biological calcium-dependant effects and dietary calcium might be
safer and more effective than traditional calcium supplements and medicines. To
increase calcium salt efficacy a new formulation of calcium salts has been
developed. It is a mixture (water suspension) of amorphous calcium carbonate,
citrate, hydrocarbonate, as well as magnesium hydrocarbonate and hydrocitrate
as stabilizers. The capacity of a cockerel’s duodenal mucosa to absorb Ca2+ after peroral ingestion of the mentioned composition in vivo was as much
as 126% higher in comparison with CaCO3 suspension intake. Vitamin D3 enhanced the amorphous
antirachitic activity of calcium salts. The aim of the study was to compare
original amorphous calcium salt composition bioavailability with Ca salts most
often in food and medicines, as well as to evaluate the antirachitic activity
of the mentioned composition in combination with vitamin D3 in
chickens.