TITLE:
Evaluation of the Blood Pressure Lowering-Effect of the Lactotripeptides Valine-Proline-Proline and Isoleucine-Proline-Proline in Non-Hypertensive Japanese Subjects through a Meta-Analysis of Randomized-Controlled Studies
AUTHORS:
Aurelie Chanson-Rolle, François Aubin, Veronique Braesco, Ryuji Takeda, Yasuhiro Saito
KEYWORDS:
Blood Pressure, IPP, VPP, Japanese, Meta-Analysis
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.9 No.10,
October
30,
2018
ABSTRACT: Several studies have reported the ability of the lactotripeptides valine-proline-proline (VPP) and isoleucine-proline-proline (IPP) to lower systolic blood pressure (SBP), including in Japanese populations. But the magnitude of the reported changes differs across trials. Conclusions from a previous meta-analysis in Japanese subjects suggest that this may be due at least partly to differences in subjects’ blood pressure (BP) status. Therefore, we decided to resume this analysis, focusing only on non-hypertensive subjects and including newly-published eligible studies, in order to further evaluate the SBP-lowering effect of VPP/IPP and study the influence of the ingested dose, type of ingredient (enzymatic or fermented) and food product (drink or supplement). The systematic search of four databases (including two in Japanese) allowed to identify 11 relevant randomized-controlled trials (581 subjects), which were included in the meta-analysis. Results reported a significant decrease in SBP following VPP/IPP intake in non-hypertensive Japanese individuals, with an estimated effect-size of -3.44 mm Hg (95% CI, -4.53 to -2.34, P