TITLE:
Trends in HIV-2 Seroprevalence at the National Reference Center of HIV from 2005 to 2014 in Lome, Togo
AUTHORS:
Amivi Amenyah- Ehlan, Mounerou Salou, Malewe Kolou, Komlan Ali- Edje, Tufa Nyasenu, Sika Dossim, Alassane Ouro- Medeli, Mensah Douffan, Anoumou Dagnra, Mireille Prince- David
KEYWORDS:
HIV-2, Seroprevalence, Togo
JOURNAL NAME:
World Journal of AIDS,
Vol.7 No.4,
November
6,
2017
ABSTRACT:
Background: In Togo, the HIV/AIDS epidemic is characterized by the circulation
of the 2 subtypes of HIV. Thus, patients infected with HIV-2 are diagnosed
and monitored in the care centers. Objective: To document the trend
of HIV-2 prevalence over a decade of activities of the National Reference
Center for HIV tests and screening (CNR-VIH). Methods: A cross sectional
study was carried out from the screening data archived from January 2005 to
December 2014 at the CNR-VIH, a laboratory located in the Sylvanus Olympio
University Hospital (CHU SO) Lome. The sampling consisted of adults
and children outpatients or those who were hospitalized in CHU SO, subjects
presenting for voluntary testing, pregnant women and patients or samples referred
for HIV confirmation. All samples were tested for HIV-1 and HIV-2
infections by combining ELISA and rapid diagnostic tests. Result: During the
decade, 34,077 subjects were screened for HIV infection. The overall prevalence
of HIV infection was 20.70% (7055/34077). In 10 years, the prevalence
of HIV infection in CNR-VIH decreased significantly from 35.40% CI95% [34.50% - 36.20%] in 2005 to 14.20% CI95% [13.60% - 14.70%] in 2014 (p =
0.03). The prevalence of HIV-1, HIV-2 and dual HIV1&HIV-2 was respectively
20.40%, 0.23% and 0.07%, with annual prevalence of HIV-2 between
0.07% and 0.39%. The differences between the HIV-2 prevalence over the
decade were not statistically significant (p > 0.15). A 4-year-old child from
mother-to-child HIV-2 transmission was diagnosed. Sixty-five percent of
adult patients were over 40 years of age with an average age of 43.5 ± 11.3
years. Conclusion: Data from the National Reference Center for HIV Tests in Togo over the last ten years confirm the existence of a weak epidemic of HIV-
2 infection with a tendency towards stability.