TITLE:
Comparison of Serum Phospholipase A2 Activities of All Known Extant Crocodylian Species
AUTHORS:
Mark Merchant, Charles McAdon, Stephanie Mead, Justin McFatter, Caleb D. McMahan, Rebeckah Griffith, Christopher M. Murray
KEYWORDS:
Antibacterial, Antimicrobial, Crocodilian, Crocodylia, Crocodylidae, Gavialidae, Innate Immunity, Phylogeny, PLA2
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.7 No.4,
August
28,
2017
ABSTRACT: Serum samples from all 23 extant crocodilian species were tested for phospholipase A2 (PLA2) activity against nine different bacterial species. The data were usedto generate a PLA2 activity profile for each crocodilian species, and the data were used to compare the activities of the three main lineages (Alligatoridae,Crocodylidae, and Gavialidae), the seven different genera, and to compare allof the 23 individual species. The data revealed that the three lineages ofcrocodilians (Alligatoridae, Crocodylidae, and Gavialidae) exhibited PLA2 activities toward nine species of bacteria that were statisticallydistinguishable. Inaddition,the PLA2 activities of crocodilians in a specific genus tended to be more similar to othermembers in their genus than to members of other crocodilian genera.