TITLE:
Prognostic Significance of Standardized Uptake Value of PET Scan in Non-Small Cell Lung Cancer
AUTHORS:
A. Alshuhayeb, S. Gilbert, A. J. E. Seely, F. M. Shamji, S. Sundaresan, P. J. Villeneuve, D. E. Maziak
KEYWORDS:
Non Small Cell Lung Cancer, SUV, PET, Prognosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.3,
March
18,
2016
ABSTRACT: Background: To determine if the maximum standardized uptake value (SUVmax)
of the primary tumor as determined by preoperative (18)F-fluoro-2-deoxyglucose
((18)F-FDG) positron emission tomography (PET) is an independent predictor of
overall survival, mediastinal lymph node metastasis, and stage in patients with
non-small cell lung cancer (NSCLC). Methods: A retrospective review of 1033
patients with stage I-IV histologically proven NSCLC who had an (18)F-FDG PET
done between 2005 and 2011 for staging before receiving therapy was performed.
SUVmax of primary NSCLC was measured and
correlated with tumor characteristics, lymph node involvement, cancer
stage and overall survival. The patients were divided into three groups
according to their SUVmax value: group I SUVmax 10. The primary outcome was survival and recurrence
rate, compared using Log Rank Test. Results: The median duration of follow up
was 675 days (22.5 months). The overall survival at two years for group I was
88%, group II 60% and group III 53%, significantly different among the three
groups (p-value