TITLE:
Particle Simulation of Skin Basal Layer Formation
AUTHORS:
Katsuya Nagayama, Takeshi Kurihara, Yasuko Amano, Masanori Tanahashi
KEYWORDS:
Numerical Simulation, Skin Formation, Particle Model, Basal Layer
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.3,
March
17,
2016
ABSTRACT:
There has been increasing
concern regarding the cosmetic aspects of skin in recent years. Computational
simulation can be useful in understanding the mechanism underlying skin
formation. The bottom of the epidermis is called the basal layer and is very undulation.
In this study, we focus on the basal layer formation. We created a particle
model, which forms an undulation basal layer and regenerates the basal layer
formation by numerical simulation. At first, two-dimensional basal layer formation without epidermal
turnover was simulated. The results showed film shape changes and the
stability, as a layer in the process of long-time with an increase and decrease
of basal cells. Next, the model was applied to three-dimensional basal layer
formation with epidermal turnover. As the structure of the basal layer was
deformed, the upper structure of the epidermis comprising the cells divided from
the basal layer also became irregular. The simulation results accurately
represented and reproduced the three-dimensional basal
layer formation and epidermis turnover process.