TITLE:
Low Efficiency of the Commonly Prescribed Drugs against Klebsiella pneumonia, Escherichia coli and Acinetobacter Species as the Causative Agents of Blood Stream Infection in Malabo, Equatorial Guinea
AUTHORS:
Aleksey Shatalov, Yaari Shilo, Rizeq Nakhash, Dennis Zhdanov
KEYWORDS:
Bacteremia, Multi Drug Resistance, ESBL, Gram Negative Rods
JOURNAL NAME:
Advances in Microbiology,
Vol.6 No.3,
March
14,
2016
ABSTRACT: The
prevalence of multi drug resistant gram-negative bacteria to commonly first line
drugs in blood is a serious problem in Equatorial Guinea and other world. This is
the first study describing antibiotic resistance analysis of blood stream infection
in Equatorial Guinea. Our study presents alarming rate of inefficiency of the most
commonly prescribed drugs to treatment Klebsiella pneumoniae, Escherichia
coli and Acinetobacter species isolates as the most frequency etiologic agents in blood stream infection.
Out of 1849 blood culture the bacterial etiological agents were isolated from 196
(10.6%) samples. E. coli (n = 22), K. pneumonia (n = 39) and Acinetobacter (n = 17) represent 71.6% of all gram negative bacterial isolates. Almost all isolates
of K. pneumonia and Acinetobacter sp. (92.1% and 100%, respectively)
and about 50% of E. coli strains possessed
extended-spectrum β-lactamase activity.
Alarming level of multi drug resistant gram negative strains was observed. E.
coli and K. pneumonia and Acinetobacter isolates demonstrated
low sensitivity to all commonly prescribed drugs such as Ampicillin, Trimethoprim/Sulfamethoxazole,
Doxycycline, Gentamycin Amoxicicline/Clavulanic Acid, Cefuroxime, Ciprofloxacine.
It is especially worth noting the low efficiency of third generation cephalosporins
(Cefrtiaxon) against Acinetobacter and Klebsiella with their resistance rate of
94.7% and 100% respectively. Moreover, the alarming level of low sensitivity to
Piperacilin/Tazobactam of K. pneumonia (22%) and Acinetobacter (29.4%)
was been found. The 17.6% of Acinetobacter isolated was carbomenem resistant. Just
Imipenem and Amikacin were the
most sensitive drug against these bacterial strains.