TITLE:
The Increased Frequency of Carbapenem Resistant Non Fermenting Gram Negative Pathogens as Causes of Health Care Associated Infections in Adult Cancer Patients
AUTHORS:
Hadir A. El-Mahallawy, Rasha M. Abdel Hamid, Safaa Shawky Hassan, Samah Radwan, Magdy Saber
KEYWORDS:
Multi Drug Resistant Organisms (MDRO), Non-Fermenting Gram Negative Bacilli (NF-GNB), Metallo-β-Lactamases (MBL), Surgical Site Infections (SSI)
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.10,
September
21,
2015
ABSTRACT: Background and Aim: Multi drug resistant Non fermenting gram negative
bacilli (NFGNB) have emerged as a major cause of health-care associated
infections especially in immunocompromised hosts. The aim of the study was to
investigate the prevalence of NFGNB as a cause of health-care associated
infections (HAI) in cancer patients and determine their resistance pattern.
Patients and Methods: During the study period, 158 NFGNB isolates were
collected. Microscan Walk Away 9 was used for identification and testing for
the metallo-β-lactamases (MBLs) was
done by Imipenem-EDTA combined disk synergy test (CDST-IPM). Results: NFGNB
represented 29.0% of infections caused by gram negative organisms. Carbapenem
resistance, the multi-drug resistant (MDR) phenotype, and MBL production were
documented in 70%, 63%, and 59% of NFGNB isolates, respectively. MDR-NFGNB
rates were significantly higher among hospitalized patients, medical department
and those with longer duration of hospital stay (p = 0.034, 0.026, 0.019; respectively) than non MDR-NFGNB. Conclusion: A high level of
carbapenem and multi-drug resistance were detected among the non-fermenter
pathogens isolated from hospitalized cases and were more frequently encountered
in high risk adult cancer patients requiring longer duration of
hospitalization. The MDR-NFGNB are constituting important causes of health-care
associated infections in cancer patients.