TITLE:
Utilizing rs-fMRI’s Mean to Localize Seizure Focus
AUTHORS:
Byron Bernal, Magno R. Guillen, Kathryn Zamora, Nolan Altman
KEYWORDS:
Epilepsy, Seizures, fMRI, Resting-State, SPECT, Intractable Epilepsy
JOURNAL NAME:
Open Journal of Radiology,
Vol.5 No.2,
June
11,
2015
ABSTRACT: Purpose:
We present for the first time the utilization of an average of the
resting-state time points (rs-Mean) to localize epilepsy focus in a group of
pediatric patients with medical refractory epilepsy. Materials and Methods: Twenty
nine pediatric patients had drug-resistant epilepsy, and 22 subject controls
underwent rs-fMRI. Comparison among group means was performed. Regions of Interest
(ROI) derived from the nuclear medicine studies (GS) and the focal
hyperintensities yielded by the rs-Mean were converted into ellipsoids.
Euclidian Distance (ED) among the isocenters of each ROI pair per patient was
found. Matching of ROIs was accepted if the ED was equal or less than 50 mm.
Group comparison was performed utilizing two-tail T-test. Statistical
significance was accepted with p values