TITLE:
A Simple and Highly Efficient Enantioselective Synthesis of (S)-Rivastigmine
AUTHORS:
Veera R. Arava, Laxminarasimhulu Gorentla, Pramod K. Dubey
KEYWORDS:
Cholinergic Agent, Enantioselective, Highly Efficient, (S)-(-)-2-Methyl-2-Propane Sulfina-mide, (S)-Rivastigmine
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.1 No.2,
June
30,
2011
ABSTRACT: A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease, is accomplished by the treatment of versatile, readily accessible (S)-(-)-2-methyl-2-propanesulfinamide with 3-hydroxyacetophenone. This protocol provides high yield and excellent enantiomeric excess in short step synthesis.