Cuvillon, P., Nouvellon, E., Ripart, J., Boyer, J.C., Dehour, L., Mahamat, A., L’Hermite, J., Boisson, C., Vialles, N., Lefrant, J.Y. and de La Coussaye, J.E. (2009) A Comparison of the Pharmacodynamics and Pharmacokinetics of Bupivacaine, Ropivacaine (with Epinephrine) and Their Equal Volume Mixtures with Lidocaine Used for Femoral and Sciatic Nerve Blocks: A Double-Blind Randomized Study. Anesthesia & Analgesia, 108, 641-649.
http://dx.doi.org/10.1213/ane.0b013e31819237f8

has been cited by the following article:

• TITLE: Reducing the Dose of Local Anesthetic Reduces the Duration of Analgesia—Myth or Reality: A Double-Blind Randomized Study

  AUTHORS: Piacherski Valery, Marachkou Aliaksei

  KEYWORDS: Ropivacaine, Sciatic Nerve, Ultrasound Guidance

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.5 No.1, January 14, 2015

  ABSTRACT: Background: The aim of the study is to determine the effect of a reduction in dose of local anesthetic blockade on the development of the sciatic nerve. Methods: Forty blocks of sciatic nerve were used in a double-blind randomized research, under ultrasonic guidance, using an electric stimulator with the peripheral nerves. Forty patients were divided into 2 equal groups. In the first group, a sciatic nerve block was performed with 5 ml of 0.75% ropivacaine solution (37.5 mg); in the second group, 10 ml of 0.75% ropivacaine solution (75 mg) was used. The assessment of the time required for developing sensory and motor blocks was carried out from the beginning of local anesthetic solution injection in the fascial sheath of the sciatic nerve. Results: Demographic data of patients were identical in the two sample groups. The time required for achieving a complete sensory block in groups treated with 5 and 10 ml ropivacaine was 45 (40; 48) and 30 (28; 30) min, respectively, (р 0.05. Conclusions: Complete blockade of the sciatic nerve is developed using 5 ml of 0.75% ropivacaine. Reducing the dose of ropivacaine prolongs the latent period of the LA during the blockade of the sciatic nerve. Time of postoperative analgesia was not significantly changed.