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has been cited by the following article:

• TITLE: Effects of Tension Force on Proliferation and Differentiation of Human Periodontal Ligament Cells Induced by Lipopolysaccharides

  AUTHORS: Yanqi Yang, Linkun Zhang, Chongshan Liao, Jiajing Lu, Chengfei Zhang

  KEYWORDS: Human Periodontal Ligament Cells, Tension Force, Lipopolysaccharides, Proliferation, Differentiation

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.2 No.3, May 9, 2014

  ABSTRACT: Human periodontal ligament cells (hPDLCs), with the potential for multi-directional differentiation and reproduction, are the target cells of orthodontic tooth movement. The aim of this study was to examine the effect of mechanical tension force and lipopolysaccharides (LPS) on hPDLCs and whether they induce proliferative and differentiated characters in vitro. Tension force was applied to hPDLCs stimulated with and without LPS for 24 hrs. Real-time polymerase chain reaction (qPCR) was carried out to analyze the mRNA expression of Cyclin 2 (CCND2), WNT1 inducible signaling pathway protein 1 (WISP1), runt-related transcription factor 2 (RUNX2) and alkaline phosphatase (ALP). Analysis of variance (ANOVA) was used for statistical analysis. Significant differences were indicated by P