TITLE:
Stem cells therapy for regenerative medicine: Principles of present and future practice
AUTHORS:
José A. Andrades, José Becerra, Ramón Muñoz-Chápuli, Salvador Martínez, Ángel Raya, Javier García-Sancho, José M. Moraleda
KEYWORDS:
Spanish Cell Therapy Network; Stem Cell; Cell Therapy; Tissue Engineering; Regenerative Medicine
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.7 No.2,
January
29,
2014
ABSTRACT: The
characterization and isolation of various stem cell populations, from embryonic
to tissue-derived stem cells and induced pluripotent stem cells (iPSCs), have
led to a rapid growth in the field of stem cell research and its potentially
clinical application in the field of regenerative medicine and tissue repair.
Stem cell therapy has recently progressed from the preclinical to the early
clinical trial arena for a variety of diseases states, although further
knowledge on action mechanisms, long-term safety issues, and standardization
and characterization of the therapeutic cell products remains to be thoroughly
elucidated. In this paper we summarize the current state of the art of basic
and clinical research that were highlighted at the 2012 meeting of the Spanish
Cell Therapy Network. This includes the current research involving in genomic
and transcriptomic characterization of selected stem cell populations, studies
of the role of resident and transplanted
stem cells during tissue regeneration and their mechanism of action,
improved new strategies of tissue engineering, transplantation of mesenchymal
stem cells (MSCs) in different animal models of disease, disease correction by
iPSCs, and preliminary results of cell therapy in human clinical trials.