Article citationsMore>>
Sánchez-Corona, J., Flores-Martínez, S.E., Machorro-Lazo, M.V., Galaviz-Hernández, C., Morán-Moguel, M.C., Perea, F.J., Mújica-López, K.I., Vargas-Ancona, L., Laviada-Molina, H.A., Fernández, V., Pardío, J., Arroyo, P., Barrera, H. and Hanson, R.L. (2004) Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings. Diabetes Research and Clinical Practice, 63, 47-55.
http://dx.doi.org/10.1016/j.diabres.2003.08.004
has been cited by the following article:
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TITLE:
Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
AUTHORS:
Fulden Sarac, Afig Berdeli, Sefa Sarac, Sumru Savas, Merve Atan, Fehmi Akcicek
KEYWORDS:
Metabolic Syndrome; Insulin Receptor Substrat-1 Gene; Insulin Receptor Substrat-2 Gene
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.4,
November
12,
2013
ABSTRACT:
Aim: Metabolic syndrome (MetS) is a major risk factor for both diabetes mellitus and cardiovascular disease (CVD). The aims of the study were 1) to investigate the insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to examine the relationships between gene polymorphisms and components of MetS. Patients & Methods: The study population included 100 patients with MetS and 30 patients without MetS as control group. Metabolic syndrome (MS) was defined as in ATP III. Entire coding exons of IRS-1 and IRS-2 genes were amplified by polymerase chain reaction (PCR). Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA). Results: In patients with MetS, 34 (34%), had G972R (rs1801278) gene polymorphism and 66 (66%) had no nucleotide substitutions at the IRS-1 gene (p circumference, blood pressure, triglyceride, HDL-Cholesterol, LDL-Cholesterol and HOMA-IR levels. Conclusion: Insulin receptor substrate-1 and 2 gene polymorphisms were associated with metabolic syndrome but not its components.
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