A. R. Ahmed, A. Dashevsky and R. Bodmeier, “Reduction in Burst Release of PLGA Microparticles by Incorporation into Cubic Phase-Forming Systems,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 70, No. 3, 2008, pp. 765-769. - References

Browse Menu >>

Browse Subjects >>

Computer Science & Communications

Earth & Environmental Sciences

Social Sciences & Humanities

Why Us? >>

- Open Access
- Peer-reviewed
- Rapid publication
- Lifetime hosting
- Free indexing service
- Free promotion service
- More citations
- Search engine friendly

Free SCIRP Newsletters>>

Add your e-mail address to receive free newsletters from SCIRP.

Contact Us >>

customer@scirp.org

+86 18163351462(WhatsApp)

1655362766

Paper Publishing WeChat

Book Publishing WeChat

(or Email:book@scirp.org)

Article citations
More>>

A. R. Ahmed, A. Dashevsky and R. Bodmeier, “Reduction in Burst Release of PLGA Microparticles by Incorporation into Cubic Phase-Forming Systems,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 70, No. 3, 2008, pp. 765-769.
http://dx.doi.org/10.1016/j.ejpb.2008.07.008

has been cited by the following article:

TITLE: One-Step Preparation of Poly-Lactic-Co-Glycolic-Acid Microparticles to Prevent the Initial Burst Release of Encapsulated Water-Soluble Proteins

AUTHORS: Hiroyuki Takabe, Moriyuki Ohkuma, Yasunori Iwao, Shuji Noguchi, Shigeru Itai

KEYWORDS: Poly-Lactic-Co-Glycolic-Acid; Microparticle; Suppression of Initial Burst Release; Coating; Bovine Serum Albumin

JOURNAL NAME: Pharmacology & Pharmacy, Vol.4 No.8, November 8, 2013

ABSTRACT: An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the development of a simple one-step coating method that suppresses the initial burst release process. This new method involves coating the PLGA-MPs with PLGA, with the coating process being performed through the phase separation of PLGA on the surface of PLGA-MPs using the emulsion-solvent evaporation method. Bovine serum albumin (BSA) was encapsulated in the PLGA-MPs as a model API. The coated MPs were spherical in shape with no pores on their smooth surface, whereas the non-coated PLGA-MPs had porous surfaces. An in vitro release study showed that the residual levels of BSA in the coated and non-coated PLGA-MPs after 1 h were about 99% and 16% of the original loads, respectively. The one-step coating method therefore represents a useful method for preparing PLGA-MPs that do not give an initial burst release of proteinaceous APIs.