K. Andreas, R. Zehbe, M. Kazubek, K. Grzeschik, N. Sternberg, H. Baumler, H. Schubert, M. Sittinger and J. Ringe, “Biodegradable Insulin-Loaded PLGA Microspheres Fabricated by Three Different Emulsification Techniques Investigation for Cartilage Tissue Engineering,” Acta Biomaterialia, Vol. 7, No. 4, 2011, pp. 1485-1495. - References

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K. Andreas, R. Zehbe, M. Kazubek, K. Grzeschik, N. Sternberg, H. Baumler, H. Schubert, M. Sittinger and J. Ringe, “Biodegradable Insulin-Loaded PLGA Microspheres Fabricated by Three Different Emulsification Techniques: Investigation for Cartilage Tissue Engineering,” Acta Biomaterialia, Vol. 7, No. 4, 2011, pp. 1485-1495.
http://dx.doi.org/10.1016/j.actbio.2010.12.014

has been cited by the following article:

TITLE: One-Step Preparation of Poly-Lactic-Co-Glycolic-Acid Microparticles to Prevent the Initial Burst Release of Encapsulated Water-Soluble Proteins

AUTHORS: Hiroyuki Takabe, Moriyuki Ohkuma, Yasunori Iwao, Shuji Noguchi, Shigeru Itai

KEYWORDS: Poly-Lactic-Co-Glycolic-Acid; Microparticle; Suppression of Initial Burst Release; Coating; Bovine Serum Albumin

JOURNAL NAME: Pharmacology & Pharmacy, Vol.4 No.8, November 8, 2013

ABSTRACT: An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the development of a simple one-step coating method that suppresses the initial burst release process. This new method involves coating the PLGA-MPs with PLGA, with the coating process being performed through the phase separation of PLGA on the surface of PLGA-MPs using the emulsion-solvent evaporation method. Bovine serum albumin (BSA) was encapsulated in the PLGA-MPs as a model API. The coated MPs were spherical in shape with no pores on their smooth surface, whereas the non-coated PLGA-MPs had porous surfaces. An in vitro release study showed that the residual levels of BSA in the coated and non-coated PLGA-MPs after 1 h were about 99% and 16% of the original loads, respectively. The one-step coating method therefore represents a useful method for preparing PLGA-MPs that do not give an initial burst release of proteinaceous APIs.

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