K. Yoshimatsu, A. Yamaguchi, H. Yoshino, N. Koyanagi and K. Kitoh, “Mechanism of Action of E7010, an Orally Active Sulfonamide Antitumor Agent: Inhibition of Mitosis by Binding to the Colchicine Site of Tubulin,” Cancer Research, Vol. 57, No. 1, 1997, pp. 3208-3213.

has been cited by the following article:

• TITLE: Efficient Synthesis of a New Class of N-Nucleosides of 4H-Thiochromeno[2,3-d]pyrimidine-10-Sulfone as Potential Anticancer and Antibacterial Agents

  AUTHORS: Abdulrahman G. Alshammari, Abdel-Rhman B. A. El-Gazzar, Hend N. Hafez

  KEYWORDS: Thiochromene; Pyrimidine; Antibacterial; Anticancer Agents

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.3A, November 5, 2013

  ABSTRACT: A highly practical and efficient preparation of 6-methy-4H-thiochromene and 7-methyl-thiochromene[2,3-d]pyrimidine derivatives was developed via a multi-component reaction of 3-methyl-thiophenol (1), aldehydes (2), and malononitrile (3). A series of pyrimidine nucleoside, thiochromene[2,3-d]pyrimidine and thiochromene[2,3-d]pyrimidine-10-sulfone was efficiently obtained. These hybrid compounds were evaluated as potential antibacterial and anticancer agents and showed encouraging biological activities. Some of these derivatives showed broad-spectrum antitumour activity against the nine tumour subpanels tested, and demonstrated significant activity in the in vitro antitumour screening expressed by MG-MID log10GI50 value of －4.55, －4.67 and －4.73 of compounds 9a, 9b and 9c, respectively.