A. B. Ackerman, N. Chongchitant, J. Sanchez, Y. Guo, B. Bennin, M. Reichel and A. B. Randall, “Embryologic, Histologic and Anatomic Ascpects,” In: A. B. Ackerman, N. Chongchitant, J. Sanchez, Y. Guo, B. Bennin, M. Reichel and A. B. Randall, Eds., Histologic Diagnosis of Inflammatory Skin Diseases, 2nd Edition, Williams and Wilkins, Baltimore, Phildelphia, London, Paris, Banckok, Hong Kong, Sydney, Tokyo, 1997, p. 2.

has been cited by the following article:

• TITLE: PUVA versus NB-UVB in Management of Vitiligo, Clinico-Immuno-Pathological Study

  AUTHORS: Sameh K. Attia, Sherif S. Awad, Siham Yacoub

  KEYWORDS: PUVA; Vitiligo; NB-UVB

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.3 No.3B, November 5, 2013

  ABSTRACT: Background: Phototherapy is the most commonly used modality in the treatment of vitiligo. Oral PUVA is the classical treatment and the NB-UVB is a recently introduced form excluding the shorter erythemogenic wavelengths. Aims: This study was designed to compare the effects of PUVA and NB-UVB clinically and immuno-pathologically in managing non segmental vitiligo. Patients/Methods: Thirty vitiligo patients were divided randomly into two groups and treated either by oral PUVA or by narrow band UVB for 4 months, and evaluation was done clinically and immuno-pathologically. Results: One patient in PUVA group (3.3%) failed to respond to therapy while 29 patients (93.3%) improved including all NB-UVB cases. Excellent repigmentation was achieved in 6.7% in PUVA group and 66.6% in NB-UVB group; good repigmentation was achieved in 60% in PUVA and 20% in NB-UVB while 26.7% in PUVA and 13.3% in NB-UVB showed mild repigmentation. The color matching was excellent in all NB-UVB patients. Recurrence and activation of vitiligo were demonstrated in some NB-UVB cases and were less in PUVA treated cases. Microscopic examination revealed persistence of dermal lympho-histiocytic infiltrate and the interface changes in biopsies from vitiliginous lesions treated with NB-UVB more than with PUVA. Conclusions: NB-UVB provides significant better results than oral PUVA in managing non-segmental vitiligo. Although NB-UVB therapy gives a rapid effect, yet the observation of recurrences and development of new lesions of vitiligo were less significant with PUVA. It was also observed that PUVA has better immuno-modulatory effect on vitiligo than NB-UVB and may give better response on a longer period of time.