TITLE:
Model-based Analysis of Ventilation Inhomogeneity in Respiratory Mechanics
AUTHORS:
Christoph Schranz, Kévin Meffray, Claudius Stahl, Knut Möller
KEYWORDS:
Respiratory Mechanics; Inhomogeneity Model; Parameter Identification; Model-Based Therapy
JOURNAL NAME:
Engineering,
Vol.5 No.10B,
November
1,
2013
ABSTRACT:
Individualized models of respiratory mechanics help to reduce
potential harmful effects of mechanical ventilation by supporting the evaluation
of patient-specific lung protective ventilation strategies. Assessing ventilation
inhomogeneities might be an important aspect in optimizing ventilator settings.
The aim of this studyis to capture and analyze ventilation inhomogeneity by a mathematical
model using clinical data. The results show that the lung physiology of mechanically
ventilated patients without lung condition can be described by an inhomogeneity
model revealing two alveolar compartments with median time constants of 0.4 and
3.9 s. Thus, the IHM in combination with specific ventilation maneuver might be
suitable to capture lung physiology for model-based optimization of ventilator settings
but requires additional image-based investigations to further support the validity
of the model.