TITLE:
Anti-Ulcerogenic Activity of the Pomegranate Peel (Punica granatum) Methanol Extract
AUTHORS:
Ghazaleh Moghaddam, Mohammad Sharifzadeh, Gholamreza Hassanzadeh, Mahnaz Khanavi, Mannan Hajimahmoodi
KEYWORDS:
Anti-Inflammatory; Indomethacine; Peptic Ulcer Disease
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.10A,
October
9,
2013
ABSTRACT:
Pomegranate (Punica granatum L.) belongs to genera Punica and family Punicaceae. It is a herbal
preparation that has been suggested as useful in the treatment of
gastrointestinal disorders. However, to our knowledge, no study has been
conducted to evaluate this therapeutic property. In the present study the
antiulcerogenic effects of pomegranate peel methanol extract, was tested on male Wistar
albino rats. Oral pretreatment with peel extracts
(25, 50 and 100 mg/kg) for 15 days protected the gastric mucosa against the
damage induced by indomethacin (50 mg/kg). The incidence of ulceration in the control group was 100%.
The best results were found in a dosage of 50 mg/kg in sour summer cultivar
which inhibited the peptic ulcerin comparison with indomethacin induced gastric
ulcer group. Lowest ulcer index (5.4 ± 0.55), an apparent
decrease in the infiltration of polymorphonuclear leukocytes and hemorrhage
were observed after administration of sour summer extracts (50 mg/kg). In conclusion present study showed
that pomegranate peel extract, especially sour summer, has curative potential as an antiulcer, possibly via its high antioxidant activity. These
results from pomegranate peel extract can provide an extra income and may
contribute about good nutritional values of this product.