Obara, T., Ohkubo, T., Kikuya, M., Asayama, K., Metoki, H., Inoue, R., Oikawa, T., Murai, K., Komai, R., Horikawa, T., Hashimoto, J., Totsune, K., Imai, Y., J-HOME Study Group (2006) The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: The Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study. Diabetes Research and Clinical Practice, 73, 276-283. http://dx.doi.org/10.1016/j.diabres.2006.01.015

has been cited by the following article:

• TITLE: The number of antihypertensive agents simply reflects the grade and the risk of atherosclerosis in patients with type 2 diabetes mellitus

  AUTHORS: Hiroyuki Ito, Mariko Abe, Masahiro Shinozaki, Takashi Omoto, Shinya Nishio, Masahide Furusho, Shinichi Antoku, Mizuo Mifune, Michiko Togane, Tsutomu Sanaka

  KEYWORDS: Hypertension; Antihypertensive Agents; Intima-Media Thickness; Ankle-Brachial Pressure Index; Pulse Wave Velocity

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.3 No.4, September 30, 2013

  ABSTRACT: Aims: The associations between the number of antihypertensive agents being taken by type 2 diabetic patients and 1) the grade of atherosclerosis according to non-invasive surrogate markers for atherosclerosis and 2) the other risk factor for atherosclerosis, were cross-sectionally investigated. Methods: The association between the blood pressure control and the clinical characteristics was evaluated in 1359 patients with type 2 diabetes mellitus. Results: The number of antihypertensive agents was 1.5 ± 1.4 (2.0 ± 1.2 among the 990 patients with hypertension). The proportion of patients taking no antihypertensive agents was 29%, 22% were taking one, 29% were taking two and 21% of the patients were taking three or more antihypertensive agents. The value of the ankle-brachial pressure index significantly decreased with the increase in the number of antihypertensive agents even if the blood pressure was corrected to the target value. The values of brachial-ankle pulse wave velocity and carotid intima-media thickness were also increased. The prevalence of risk factors for atherosclerosis, such as obesity, hyperlipidemia, chronic kidney disease, hyperuricemia and anemia was significantly elevated with the number of agents. Conclusions: The number of antihypertensive agents simply reflects the grade and risk of atherosclerosis in patients with type 2 diabetes mellitus.