TITLE:
The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles
AUTHORS:
Dong Jin Ryu, Jin Young Jung, Kee Yang Chung, Hwal Suh, Sang Ho Oh, Ju Hee Lee
KEYWORDS:
Adenosine; Succinylated Atelocollagen; Periorbital Wrinkles
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.3 No.3,
September
27,
2013
ABSTRACT:
The degradation
of structural collagen contributes to the characteristic appearance of wrinkles.
The anti-wrinkle effects of a variety of substances have been studied, but the potential
anti-wrinkle effects of topical applications of collagen for periorbital
wrinkles have not been investigated. To evaluate the effects of topical
application of succinylated atelocollagen on periorbital wrinkles and to
compare the results of treatment with adenosine, a clinical study on Korean participants was carried
out. Each participant’s right
or left periorbital area was treated with either a solution containing succinylated
atelocollagen and adenosine or a solution containing only succinylated
atelocollagen for two months. A placebo solution was applied to the opposite periorbital
area of each patient’s face for two months. Based on objective and subjective measurements
of clinical improvement, the assessment scores for treated sites were
statistically significantly higher than scores for placebo sites after two
months of treatment. Analysis of silicone casts of periorbital wrinkles
demonstrated partial effects of succinylated atelocollagen on periorbital
wrinkles. However, we did not observe any effects of adenosine on periorbital
wrinkles. Succinylated atelocollagen may be an effective treatment option for periorbital
wrinkles, but further studies including a longer treatment period and larger
subject group are needed to verify these results.