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K. Z. Guyton and T. W. Kensler, “Oxidative Mechanisms in Carcinogenesis,” British Medical Bulletin, Vol. 49, No. 3, 1993, pp. 523-544.

has been cited by the following article:

  • TITLE: Evaluation of Glutathione, Albumin and Ascorbic Acid Levels in Breast Cancer Patients

    AUTHORS: P. Faizal, B. Satheeshan, Milind Kumar, A. K. Adarsh, R. Shilpa, P. Roshni, T. Remya, K. T. Augusti

    KEYWORDS: Free Radicals; Antioxidants; Reactive Oxygen Species

    JOURNAL NAME: International Journal of Clinical Medicine, Vol.4 No.9, September 20, 2013

    ABSTRACT: Recently, an increase of global incidence has been observed for various types of cancers. Diet, lifestyle and environmental factors have an evident correlation to the development of breast cancer. Breast cancer is one of the leading causes of cancer related death in women. Several studies also revealed that excessive free radical generation and decreased antioxidant status had been implicated in cancer. These factors rekindled our interest upon the interaction of free radicals and antioxidants and hence the present study was undertaken to evaluate the significance of non enzymic antioxidants: glutathione, albumin and ascorbic acid levels in breast cancer patients. The study population was divided into 3 groups as follows: Group I control subjects (age group 21-60), Group II: breast cancer Patients (age group 21-35) and Group III breast cancer patients (age group 36-60). Highly statistically significant increases in glutathione, albumin and ascorbic acid levels were observed in Group I as compared to other groups. No significant differences in glutathione, albumin and ascorbic acid levels were observed in a group comparison between Group II and Group III. This relative decline of non enzymic antioxidants in breast cancer patients may be due to an increased generation of reactive oxygen species or free radicals. The results obtained emphasize the need of more detailed study involving a large number of newly detected cancers for evaluating the role of these antioxidant parameters in the prevention of cancer.