TITLE:
Aluminum-Magnesium Silicate enhances release of virions of cultured Fowl Pox Virus and inhibits the virus
AUTHORS:
Maduike C. O. Ezeibe, Emmanuel Ekeanyanwu, Augustine A. Ngene, Ijeoma J. Mbuko
KEYWORDS:
Aluminum-Magnesium Silicate–Nanoparticles; Antiviral Effects; Anticancer Potentials; Fowl Pox Virus
JOURNAL NAME:
Health,
Vol.5 No.9,
September
12,
2013
ABSTRACT:
Antiviral effects of
a synthetic Aluminum-Magnesium Silicate (AMS) were tested on Fowl Pox Virus (FPV). Five batches of
the Nigerian brand of FPV vaccine were used
as sources of the virus. The reconstituted vaccines were mixed with The Synthetic AMS on equal volume to
weight basis and incubated at room temperature for one hour. They were
centrifuged for 10 minutes at 2000 revolutions per minute. The incubation and
centrifugation were repeated on a portion of each vaccine supernatant. The
two sets of supernatants were tested by the Modified Passive Haemagglutination
test, for FPV titres. Portions of the vaccines, not incubated with the AMS, were
served as controls. Fowl Pox Virus titres of the vaccines
increased from a mean of 2.8 ± 1.10 to 11.2 ± 4.38 when incubated with the AMS
once. When incubation with the AMS was repeated, the titres reduced (P