Article citationsMore>>
K. V. Katok, Y. Bolbukh and V. A. Tertykh, “Chemical Modification of Silica Surface by Immobilization of Amino Groups for Synthesis of Silver Nanoparticles, NATO Science Series II. Mathematics, Physics and Chemistry,” In: M. Vaclavikova, K. Vitale, G. Gallios and L. Ivanicova, Eds., Water Treatment Technologies for Removal of High-Toxicity Pollutants, Springer, New York, 2009, pp. 283-287. doi:10.1007/978-90-481-3497-7_29
has been cited by the following article:
-
TITLE:
Controlled Release of Diclofenac Sodium from Silica-Chitosan Composites
AUTHORS:
R. B. Kozakevych, Y. M. Bolbukh, V. A. Tertykh
KEYWORDS:
Drug Incorporation; Diclofenac Sodium; Silica-Chitosan Composites
JOURNAL NAME:
World Journal of Nano Science and Engineering,
Vol.3 No.3,
September
5,
2013
ABSTRACT:
The release profiles of acidic form of diclofenac sodium adsorbed on mesoporous silicas (Silochrom and two samples of spherical silicas) were compared with the dissolution characteristics of the pure drug. Desorption of diclofenac sodium from impregnated silicas with various surface liophilicity and composites of silica with chitosan have been studied using rotating basket method in phosphate buffer, pH 6.8. Sedimentations of sodium diclofenac via adsorption and impregnation from alcohol solution on fumed silica and modified silicas with grafted aminopropyl and trimethylsilyl groups were carried out. Polymer-containing composites have been prepared by capsulation of silica particles with impregnated diclofenac sodium by protonated and deprotonated forms of chitosan. Effect of the silica surface nature on the active substance release rate was ascertained. Significant prolongation of diclofenac sodium release was detected in the case of application of hydrophobic silica as a carrier and protonated chitosan as a polymeric shell.
Related Articles:
-
Xiaolian Liao, Shangzhao Li, Guohua Chen
-
Kshama Parajuli, Aravind Kumar Sah, Hari Paudyal
-
Babak Amini
-
Flavia Denaday
-
Yasemin Gulecal, Mustafa Temel