J. Wetterslev, K. Thorlund, J. Brok and C. Gluud, “Trial Sequential Analysis May Establish When Firm Evidence Is Reached in Cumulative Meta-Analysis,” Journal of Clinical Epidemiology, Vol. 61, No. 1, 2008, pp. 64-75. doi:10.1016/j.jclinepi.2007.03.013

has been cited by the following article:

• TITLE: Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis

  AUTHORS: Andrea Messori, Valeria Fadda, Dario Maratea, Sabrina Trippoli

  KEYWORDS: Chemotherapy; Ovarian Cancer; Trial-Sequential Analysis; Futility

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.7, September 4, 2013

  ABSTRACT: In patients with epithelian ovarian cancer who have achieved remission after initial surgery and induction chemotherapy, the role of maintenance chemotherapy is controversial. We carried out a trial-sequential analysis that included 4 randomised controlled trials. The end-point was progression at 3 years while the boundary for non-inferiority was set at ±20% in risk ratio. The results of our trial-sequential analysis indicated the futility of maintenance chemotherapy, i.e. proof of no effectiveness. Consequently, no further trials of this type should be performed to assess the effectiveness of this intervention in this clinical condition.