TITLE:
Dissociative decline of spatial learning and recall with aging in male CD-1 mice
AUTHORS:
Katharina L. Neumeister, Peter Lohmann, Matthias W. Riepe
KEYWORDS:
Spatial Learning; Maze; CD-1; Middle-Aged; Old; Recall; Retrieval; Acquisition; Encoding; Memory; Running Speed
JOURNAL NAME:
Open Journal of Psychiatry,
Vol.3 No.4,
September
2,
2013
ABSTRACT:
On aging, spatial memory declines
to some degree in both, rodents and humans. It is unknown,
however, whether aging brings about a decline of encoding and retrieval of spatial
information in parallel. The present study examined spatial encoding and retrieval
in male CD-1 mice at 4, 9, and 12 months of age in a complex dry-land maze. The
total time to reach the goal zone was age-dependent favoring mice at 4 months of
age. We showed previously that moving time represents encoding of spatial information
and resting time represents recall of previously learned spatial information. The
average moving time decreased from 69.8 ± 5.3 s (mean ± SEM), 69.7 ± 8.0 s, and
78.9 ± 4.9 s to 17.0 ± 2.3 s (p