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has been cited by the following article:

• TITLE: Novel intron 2 polymorphism in the melanophilin gene is in Hardy-Weinberg equilibrium and is not associated with coat color in goats

  AUTHORS: Mufliat A. Adefenwa, Brilliant O. Agaviezor, Sunday O. Peters, Matthew Wheto, Oludotun J. Ekundayo, Moses Okpeku, Bola O. Oboh, Khalid O. Adekoya, Christian O. N. Ikeobi, Marcos De Donato, Bolaji N. Thomas, Ikhide G. Imumorin

  KEYWORDS: Coat Color; Goats; Melanophilin; Nigeria; Intron 2; SNP; PCR-RFLP

  JOURNAL NAME: Open Journal of Genetics, Vol.3 No.3, August 28, 2013

  ABSTRACT: Pigmentation plays important adaptation and physiological efficiency roles in animals. In the sequence of a 648 bp fragment representing intron 1, exon 2, and part of intron 2 of the MLPH mammalian pigmentation gene, we identified a novel g.469C> G mutation in intron 2, and genotyped it in 266 Nigerian goats using PCR-RFLP analysis. The C allele had frequencies of 0.9625, 0.9804 and 0.97405 in West African Dwarf (WAD),Sahel(SH) and Red Sokoto (RS) breeds, respectively. The G allele was the highest in WAD (0.0375), followed by RS (0.02595), and then SH (0.0196). Overall low FIS and FST and high Nm values demonstrate little differentiation within and among the goat breeds at this intronic locus. This g.469C> G polymorphism in MLPH gene is the first in any goat breed and also first in Nigerian goats. Our results suggest that this intronic SNP locus is maintained at Hardy-Weinberg equilibrium (P