Article citationsMore>>
Saito, A., Miyauchi, N., Hashimoto, T., Karasawa, T., Han, G.D., Kayaba, M., Sumi, T., Tomita, M., Ikezumi, Y., Suzuki, K., Koitabashi, Y., Shimizu, F. and Kawachi, H. (2011) Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys. American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, 300, R340-R348. doi:10.1152/ajpregu.00640.2009
has been cited by the following article:
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TITLE:
Novel genomic biomarkers for acute gentamicin nephrotoxicity in dog
AUTHORS:
James Eric McDuffie, Jingjin Gao, Jingying Ma, David La, Anton Bittner, Manisha Sonee, Matthew Wagoner, Sandra Snook
KEYWORDS:
Biomarker; Gentamicin; Nephrotoxicity; Dog
JOURNAL NAME:
Open Journal of Molecular and Integrative Physiology,
Vol.3 No.3,
August
28,
2013
ABSTRACT:
Objectives: Novel biomarkers indicative of drug-induced
kidney injury (DIKI) in dogs would have significant application in
preclinical drug development. We conducted a feasibility study to identify
genomic expression profiles for monitoring progressive, acute DIKI in dogs.
Materials and Methods: Animals were intramuscularly administered either 0.9%
physiological saline or gentamicin (40 mg/kg/day) for 10 consecutive days
and euthanized on day 11. Serum and urine samples were collected at various
time points and kidney samples were collected at necropsy for biomarker
measurements. Results: Acute gentamicin-induced renal histopathology changes
were localized to the proximal convoluted tubules and characterized as slight-to-marked,
diffuse cortical-medullary tubular epithelial degeneration/necrosis. Serum creatinine
(sCr) and blood urea nitrogen (BUN) elevations suggestive of mild renal
dysfunction were first observed on days 7 to 8. Gentamicin-induced increased urinary kidney
injury molecule-1 (KIM-1) mRNA was observed on day 6 preceding
detectable elevations of sCr and/or BUN. Increased urinary KIM-1 mRNA
correlated with multifocal KIM-1 immunostaining in the corticomedullary tubular
epithelial cells. Microarray analysis revealed changes in additional mRNA
expression products detected in urine and/or kidney that should be further
investigated for use as potential biomarkers for acute gentamicin related
nephrotoxicity in dogs. Conclusion: These findings suggested the utility of
non-invasive urinary genomic parameters for monitoring acute DIKI in dogs.
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