Tikunov, A., Johnson, C.B., Pediaditakis, P., Markevich, N., Macdonald, J.M., Lemasters, J.J. and Holmuhamedov, E. (2010) Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria. Archives of Biochemistry and Biophysics, 495(2), 174-181. doi10.1016/j.abb.2010.01.008 - References

Browse Menu >>

Browse Subjects >>

Computer Science & Communications

Earth & Environmental Sciences

Social Sciences & Humanities

Why Us? >>

- Open Access
- Peer-reviewed
- Rapid publication
- Lifetime hosting
- Free indexing service
- Free promotion service
- More citations
- Search engine friendly

Free SCIRP Newsletters>>

Add your e-mail address to receive free newsletters from SCIRP.

Contact Us >>

customer@scirp.org

+86 18163351462(WhatsApp)

1655362766

Paper Publishing WeChat

Book Publishing WeChat

(or Email:book@scirp.org)

Article citations
More>>

Tikunov, A., Johnson, C.B., Pediaditakis, P., Markevich, N., Macdonald, J.M., Lemasters, J.J. and Holmuhamedov, E. (2010) Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria. Archives of Biochemistry and Biophysics, 495(2), 174-181. doi:10.1016/j.abb.2010.01.008

has been cited by the following article:

TITLE: Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan

AUTHORS: Takuya Ichimura, Mika Ito, Kiyoshi Takahashi, Kyohei Oyama, Koichi Sakurai

KEYWORDS: Mitochondrial Swelling; Cytochrome C Release; Calcium; Alloxan; Mitochondrial Permeability Transition

JOURNAL NAME: Journal of Biophysical Chemistry, Vol.2 No.1, February 22, 2011

ABSTRACT: An early event in the induction of apoptosis is cytochrome c (Cyt c) release from mitochondria. We investigated the involvement of mitochonrial permeability transition (MPT) and mitochondrial swelling in Cyt c release from mitochondria treated with alloxan and/or calcium (Ca2+). When mitochondria were treated with a high concentration of Ca2+. alone or Ca2+. with alloxan (alloxan-Ca2+), the MPT was accompanied by mitochondrial swelling and the release of Cyt c. Cyclosporin A prevented the induction of MPT but only slightly decreased the release of Cyt c. High molecular weight polyethylene glycol almost completely inhibited MPT-dependent osmotic mitochondrial swelling and Cyt c release. However, MPT-independent mitochondrial swelling and Cyt c release induced by exogenous K+. were inhibited by the high molecular weight polyethylene glycol. Ruthenium red strongly decreased the amount of Cyt c released. These results suggest that mitochondrial swelling but not MPT is necessary for Cyt c release induced by Ca2+ alone or alloxan and Ca2+.