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Article citations


P. Libby, G. Sukhova, R. T. Lee and Z. S. Galis, “Cytokines Regulate Vascular Functions Related to Stability of the Atherosclerotic Plaque,” Journal of Cardiovascular Pharmacology, Vol. 25, Suppl 2, 1995, pp. S9-S12. doi:10.1097/00005344-199500252-00003

has been cited by the following article:

  • TITLE: Effect of Anti-TNF Therapy on Resistance to Insulin in Patients with Rheumatoid Arthritis

    AUTHORS: Mario Pérez, Raul Ariza, Ruben Asencio, Adolfo Camargo, Heladia Garcia, Miguel Angel Vazquez, Leonor Barile-Fabris

    KEYWORDS: Anti-TNF; Resistance to Insulin; Rheumatoid Arthritis

    JOURNAL NAME: Open Journal of Rheumatology and Autoimmune Diseases, Vol.3 No.3, August 16, 2013

    ABSTRACT: Objective: To evaluate the effect of anti-TNF therapy on resistance to insulin in patients with rheumatoid arthritis (RA) compared with patients with RA being treated with non-biological DMARDs. Methods: Inactive patients diagnosed with RA (ACR 1987 criteria) (DAS 28 2.6) were included, being treated with anti-tumor necrosis factor inhibitors (anti-TNF) (cases) and non-biological disease-modifying anti-rheumatic drugs (DMARD) (controls), without risk factors for insulin resistance (administration of steroids, body mass index > 25 kg/m2, diabetes mellitus or use of glucose lowering agents, systemic arterial hypertension or use of anti-hypertensive drugs, triglycerides > 150 mg/dl, hypercholesterolemia > 200 mg/dl, high-density lipoproteins 40 mg/dl in men and 50 mg/in women, or with lipids lowering agents, waist measurement > 88 cm in women and > 102 cm in men). We used HOMA (Homeostasis Model Assessment) to determine insulin resistance in both groups, HOMA being defined as >1 and sensitivity to insulin using QUICKI (Insulin Sensitivity Check Index), ≥0.38 being considered as normal. The Mann Whitney U was used for the statistical analysis. Results: A total of 28 patients, 15 being treated with non-biological DMARDs and 13 with anti-TNF therapy, were evaluated; 89.7%, of which were women. Average age: 43.5 (range 21 - 62); the average HOMA index of the non-biological DMARD group was 1.58 (range 0.7 - 5.4), compared with patients treated with anti-TNF therapy, 1.18 (range 0.2 - 4.3) (P = 0.5). The average QUICKI index was 0.36 (range 0.30 - 0.42) in patients treated with non-biological DMARD, compared with0.37 inpatients treated with anti-TNF therapy (range 0.30 - 0.51) (P = 0.8). Conclusion: Resistance to insulin manifested itself in both groups, although there was a greater trend of less insulin resistance and greater sensitivity in the anti-TNF group; this was probably not statistically significant due to the sample size.